illumiSonics Inc. - Photoacoustic Remote Sensing (PARS) microscopy
Similar to ultrasound imaging, traditional photoacoustic imaging systems require a coupling media, such as water or ultrasound gel, in between the ultrasound detector and the sample. This limits the use of these imaging systems in several clinical applications including wound healing, burn diagnostics, surgery, brain imaging, and many other endoscopic procedures where physical contact is impractical or undesirable as it may cause further damage or infection.There are also significant depth limitations to cellular-resolution, optically-focused, bio-microscopy which are hampering our ability to unravel cellular information at depths beyond ~1mm in living subjects. Development of a non-contact deep cellular-resolution PA is essential for many clinical and pre-clinical applications.
We recently pioneered a new technique (Photoacoustic Remote Sensing - PARS) that allows photoacoustic imaging without the need for any coupling media. This technique uses all-optical detection to remotely detect the photoacoustic signals through air and is capable of providing real-time imaging with cellular resolution. To achieve this, we use two laser beams at different wavelengths. One is visible light used to generate the signal, while the other is near-infrared invisible light used to detect the signal. The energy of these beams are very low and not harmful to tissue. PARS can provide breath-taking images of blood vessels down to the capillary level and can even visualize individual red blood cells in real-time.
PARS is also capable of visualizing physiologically important parameters such as the oxygen saturation of blood vessels and can be used to distinguish arteries and veins. This is important for various disease including cancer, diabetes, and ischemia. We believe that this technology will have significant impact in visualizing and understanding cancer biology, as well, impacting dermatological application and even enabling functional brain imaging.
Optical engineer will contribute to developing future, state-of-the-art medical device platforms. Work alongside experts in various scientific, medical and engineering disciplines to develop breakthrough photoacoustic imaging systems for several clinical and pre-clinical applications.
- Meet regularly with the director of illumiSonics to define, discuss, prioritize and review tasks.
- Align and maintain optical systems (commercial products and custom designs).
- Based on existing designs, assemble and optimize custom photoacoustic microscopes.
- Execute diverse engineering tasks related to the development of medical devices; from concept and development through to commercialization.
- Write and edit code in scientific computing and automation software (e.g. MATLAB, Python, LabVIEW, C).
- Design and build prototypes, integrate and evaluate systems.
- Define, develop, and document system- and subsystem-level requirements and their corresponding evaluation procedures.
- Keep up to date with technology trends.
- Perform optical designs and simulations in software such as ZEMAX.
- Clearly explain design concepts, theory of operation, and instructions to researchers in the biological sciences.
- Degree in Engineering, Physics, Optics or Optical Engineering.
- Ability to work efficiently and prioritize multiple project tasks.
- Strong hands-on experience in optical design.
- Strong technical aptitude in optical engineering theory, principles, and practice.
- Ability to align and maintain complicated optical systems.
- Ability to perform optical designs and simulations in appropriate software such as ZEMAX.
- Ability to create optomechanical designs using 3D CAD modeling software packages such as Autodesk Inventor.
- Ability to clearly explain design concepts, theory of operation, and instructions to researchers in the biological sciences.
- Excellent communication, verbal, and written skills.
For more information check out our website: http://www.illumisonics.com/
Postion will be based at our facility in Waterloo, Ontario, Canada.
We welcome applications from all qualified individuals including women, members of visible minorities and Aboriginal peoples.