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Postdoc Fellow at Massachusetts General Hospital/Harvard Medical School

Martinos Center for Biomedical Imaging at MGH/HMS, Charlestown, MA, United States
Employer Description

Yu Lab – Translational Neuroimaging and Neural Control Laboratory (TNNC)

Martinos Center for Biomedical Imaging, Massachusetts General Hospital

By combining optical imaging methods, e.g. fiber photometry and multi-photon imaging, with functional MRI, we aim to map brain function across different scales from cellular, to circuit-specific, and eventually to the systems levels.  To build the multi-modal fMRI platform, we plan to build an MR-compatible miniaturized imaging device, with the capability to be merged with RF sensing and electrophysiological devices. The TNNC Laboratory at Massachusetts General Hospital has led the way in developing a new paradigm through the invention and optimization of photonic crystal fiber array and implementation of MR-compatible CMOS chips for novel optical imaging modalities that enable brain functional mapping of free-moving behaving animals and head-fixed animals inside MR scanners.

Led by Dr. Xin Yu, the TNNC lab has access to 4.7T, 9.4T, and 14T horizontal MR scanners, and also multiple 3T and 7T human MR scanners. There are also RF engineering, Fiber photometry, and neural network computational units inside the TNNC laboratories. The TNNC lab provides a highly interdisciplinary research environment.  Strong national and international collaboration has been developed to implement novel multi-modal neuroimaging tools to end-users across different fields.   

Job Description

Job Description

A Postdoctoral research fellowship in the area of In Vivo neuroimaging is available in the TNNC lab led by Dr. Xin YU (tnnc.mgh.harvard.edu) at the Massachusetts General Hospital (MGH) in the Martinos Center for Biomedical Imaging.  MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new neuroimaging technologies with applications in basic and clinical research.

The fellowship will focus on the development of advanced in vivo MR compatible and implantable optical imaging devices, including fiber photometry and multi-photon imaging technologies, in the existing 14T MR scanner environment. The specific aim of the fellowship can be tailored to meet individual goals, which will provide an opportunity to build clinical, research, and publication experience.

Representative recent publications from the lab include:

·         Sobczak F, Pais-Roldán P, Takahashi K, Yu, X, Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation, eLife, (In press).

·        Pais-Roldán P, Takahashi K, Sobczak F, Chen Y, Zhao X, Zeng H, Jiang Y, Yu X. Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6875-6882. PMID: 32139609.

·        Chen X, Sobczak F, Chen Y, Jiang Y, Qian C, Lu Z, Ayata C, Logothetis NK, Yu X. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus. Nat Communications. 2019 11 20; 10(1):5239. PMID: 31748553.

·        He, Y., Wang, M., Chen, X., Pohmann, R., Polimeni, J.R., Scheffler, K., Rosen, B.R., Kleinfeld, D., and Yu, X. (2018). Ultra-slow single vessel BOLD and CBV-based fMRI spatiotemporal dynamics and their correlation with neuronal intracellular calcium signals. Neuron,  97:1-15. doi/10.1016/j.neuron.2018.01.025

·        Wang, M., He, Y., Sejnowski, T.J., and Yu, X. (2018). Brain-state dependent astrocytic Ca2+ signals are coupled to both positive and negative BOLD-fMRI signals. Proc Natl Acad Sci U S A, 115(7):E1647-E56. doi: 10.1073/pnas.1711692115. PubMed PMID: 29382752; PMCID: PMC5816146.

·        Yu X*, Qian C., Chen D-Y, Dodd S, and Koretsky A*, Deciphering laminar-specific neural inputs with line-scanning fMRI, Nature Methods, 11, 55–58. (2014) * corresponding authors. 

·        Yu X*, He Y, Wang M, Merkle H, Dodd SJ, Silva AC, Koretsky A* Sensory and optogenetically driven single-vessel fMRI, Nature Methods  13 (4)  337-340. (2016) *Corresponding author.

Job Requirements

Job Requirements

A PhD (or equivalent) in Biomedical Engineering, Electrical Engineering, Physics, Neuroscience, or a related field is required. Demonstrated excellence in one of the various forms of optical imaging, Fiber photometry, electrophysiology, or other in vivo neuroimaging or recording techniques is required. Additionally, expertise in one or more of the following areas is desired: optical imaging systems, optical design, circuit design, optical system fabrication, fiber optic systems and components, broadband light source development, spectroscopy, image processing, programming, and clinical studies with novel devices. Creativity is highly desirable.

Contact Information

Interested candidates are encouraged to send a CV accompanied by a cover letter describing any previous research training, specific areas of interest, and contact information for three letters of reference. Address correspondence to Dr. Xin Yu, note the position you are applying for in the subject line and send by email to  xyu9@mgh.harvard.edu

04 May 2022
03 June 2022
53000 – 60000
Biomedical, Medical Imaging, Health Care (Biophotonics)