Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body.
Led by Guillermo (Gary) Tearney, MD, PhD, the lab’s 70-person multidisciplinary team invents, validates and translates novel devices that use light to conduct microscopy in living patients. Light is uniquely well suited for noninvasively interrogating the microscopic structure, molecular composition and biomechanical properties of biological tissues. The goal of the laboratory’s research is to improve understanding and diagnosis of disease by imaging the human body at the highest possible level of detail in vivo.
A Postdoctoral research fellowship in the area of In Vivo Microscopy is available in the Tearney Lab (www.tearneylab.org) at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow at Harvard Medical School. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new in vivo microscopy technologies with applications in basic and clinical research.
The fellowship will focus on the development and clinical application of advanced in vivo microscopy imaging devices, including endoscopic OCT, multimodality OCT, high-resolution OCT, spectroscopic OCT, FFOCM, confocal microscopy, SECM, capsule endomicroscopy, oblique-backscattering microscopy (OBM), and related technologies. The specific aim of the fellowship can be tailored to meet individual goals, which will provide an opportunity to build clinical, research, and publication experience.
Clinical applications of these technologies include diagnosis of cancer in the gastrointestinal and pulmonary tracts, and diagnosis of atherosclerosis in the cardiovascular system.
Representative recent publications from the lab include:
- Leung HM, et al., Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies. Sci Transl Med. 2019;11(504).
- Yin B, et al., Extended depth of focus for coherence-based cellular imaging. Optica. 2017;4(8):959-65.
- Nishimiya K, et al., Micro-Optical Coherence Tomography for Endothelial Cell Visualization in the Coronary Arteries. JACC Cardiovasc Imaging. 2019;12(9):1878-80.
- Gora MJ, et al., Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video). Gastrointest Endosc. 2018;88(5):830-40 e3.
A PhD (or equivalent) in Biomedical Engineering, Electrical Engineering, Physics or a related field is required. Demonstrated excellence in one of the various forms of optical coherence tomography, confocal microscopy, or other in vivo microscopy techniques is required. Additionally, expertise in one or more of the following areas is desired: optical imaging systems, optical design, circuit design, optical system fabrication, fiber optic systems and components, broadband light source development, spectroscopy, image processing, programming, and clinical studies with novel devices. Creativity is highly desirable.