A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow or instructor at Harvard Medical School, commensurate with the applicant’s experience. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new OCT technologies with applications in basic and clinical research.
The fellowship will focus on high resolution OCT imaging devices, including development of novel optical techniques, engineering of in vivo endoscopic probes, and translation to clinical use. Examples of current medical applications of micro-OCT include imaging of mucociliary clearance to monitor treatment response in pulmonary disorders such as cystic fibrosis, high-resolution imaging of vulnerable plaques in coronary artery disease, and screening for gastrointestinal cancers using swallowable OCT capsules. The ideal candidate for this position is an organized and creative problem-solver with advanced optics, biomedical engineering, computational methods, and image analysis skills, capable of leading a multidisciplinary research team.
Representative recent publications from our group include:
Liu L, et al. Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nature Medicine 17(8), 1010-4 (2011).
Gora MJ, et al. Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure. Nature Medicine19(2), 238-40 (2013).
Ughi GJ, et al. Clinical Characterization of Coronary Atherosclerosis with Dual-Modality OCT and Near-Infrared Autofluorescence Imaging. JACC Cardiovascular Imaging 9(11), 1304-14 (2016).
Yin B, et al. Extended depth of focus for coherence-based cellular imaging. Optica 4, 959-965 (2017).
Gora MJ, et al. Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video). Gastrointestinal Endoscopy 88(5), 830-840 (2018).